Feuerstein G, Jimerson D C, Kopin I J
Am J Physiol. 1981 Mar;240(3):R166-74. doi: 10.1152/ajpregu.1981.240.3.R166.
The effects of prostaglandins (PGE2 and 16,16-dimethyl-PGE1) on epinephrine (E) and norepinephrine (NE) release, in response to a hypotensive stimulus (bleeding 5 ml/300 g), were studied in relation to blood pressure and heart rate responses in the rat. PGE2 (10 micrograms/kg-1 . min-1) and 16,16-dimethyl-PGE1 (1 microgram . kg-1 . min-1) accelerated blood pressure and heart rate recovery rate following acute hemorrhage and increased plasma E and NE levels. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenylglycol (DHPG) were not affected by PG infusion. In bilaterally nephrectomized rats, PGE2 increased plasma levels of E, NE, and DHPG but failed to enhance the blood pressure and had only a mild effect on heart rate recovery following bleeding. In hexamethonium-treated rats, infusion of PGE2 had a small and transient effect on blood pressure recovery, but its effect on the heart rate was not affected; NE and E levels in the plasma of the hexamethonium-treated rats were still higher in the PGE2-infused rats. These studies indicate that in the intact rat, administered PGE potentiate the release of E and NE and facilitate blood pressure and heart rate recovery following acute hemorrhage. The hemodynamic effects of the PGE appear to be mediated by a renal factor whereas the effects of PGE on E and NE response to hemorrhage are independent of the presence of intact kidneys.
研究了前列腺素（PGE2和16,16 - 二甲基 - PGE1）对肾上腺素（E）和去甲肾上腺素（NE）释放的影响，以及在大鼠中对低血压刺激（失血5 ml/300 g）的反应与血压和心率反应的关系。PGE2（10微克/千克 -1·分钟 -1）和16,16 - 二甲基 - PGE1（1微克·千克 -1·分钟 -1）加速急性出血后血压和心率的恢复率，并增加血浆E和NE水平。3 - 甲氧基 - 4 - 羟基苯乙二醇（MHPG）和3,4 - 二羟基苯乙二醇（DHPG）的血浆水平不受PG输注的影响。在双侧肾切除的大鼠中，PGE2增加血浆E、NE和DHPG水平，但未能提高血压，对出血后心率恢复仅有轻微影响。在六甲铵处理的大鼠中，输注PGE2对血压恢复有微小且短暂的影响，但其对心率的影响未受影响；在输注PGE2的六甲铵处理大鼠血浆中，NE和E水平仍较高。这些研究表明，在完整大鼠中，给予PGE可增强E和NE的释放，并促进急性出血后血压和心率的恢复。PGE的血流动力学效应似乎由一种肾因子介导，而PGE对出血时E和NE反应的影响与完整肾脏的存在无关。
