Wendler D, Schmidt W, Gabler W
Anat Anz. 1980;148(2):105-14.
We investigated the action of the lathyrogenic compound aminoacetonitrile (300 mg/kg body weight) on fetogenesis of the Wistar rat. In a 1st section we dealt with influence on the outer body shape and common reproductive parameters (WENDLER and coworkers 1980). This 2nd section describes toxic effects on internal organs and malformations on organ systems detected by free-hand razor blade technique. Especially, we observed cardial ectopia, rupture of the ascendant aorta, situs inversus, hydrocephalia, hydronephroses, and dystopic kidneys. Enlargement of heart atria, and main thoracic veins, dilatations of salivary gland ducts and bronchial tree are considered to be nonspecific toxic effects of aminoacetonitrile.
我们研究了致跛行化合物氨基乙腈（300毫克/千克体重）对Wistar大鼠胚胎发育的作用。在第一部分中，我们探讨了其对外部身体形态和常见生殖参数的影响（温德勒及其同事，1980年）。第二部分描述了通过徒手剃须刀片技术检测到的对内部器官的毒性作用以及器官系统的畸形。特别是，我们观察到心脏异位、升主动脉破裂、内脏反位、脑积水、肾盂积水和异位肾。心房和主要胸静脉增大、唾液腺导管和支气管树扩张被认为是氨基乙腈的非特异性毒性作用。
