Wendler D, Schmidt W, Gabler W
Anat Anz. 1980;147(5):413-23.
We investigated the influence of the lathyrogenic compound aminoacetonitrile (AAN) on fetogenesis of the rat. In late pregnancy AAN induces nonspecific toxic effects resulting in hemorrhages, edema, disturbance of weight development, and severe interaction with viability. In fetogenesis AAN induces malformation rates of 100% by contrast with the developmental stages of blastogenesis and embryogenesis. Furthermore, the present paper deals with gross anomalies after application of AAN in fetogenesis. We observed: disturbances of outer body shape, micrognathia, wrist-drop, malrotation of hind extremities, kinked tails, humpback, cardial ectopia. The paper will consist of 4 parts dealng with anomalies of organ systems, skeletal abnormalities, the mechanisms of action of lathyrogenic compounds.
我们研究了致跛化合物氨基乙腈（AAN）对大鼠胎儿发育的影响。在妊娠后期，AAN会引发非特异性毒性作用，导致出血、水肿、体重发育障碍以及与生存能力的严重相互作用。在胎儿发育过程中，与胚泡形成和胚胎形成的发育阶段相比，AAN诱导的畸形率为100%。此外，本文探讨了在胎儿发育过程中应用AAN后的明显异常。我们观察到：身体外形紊乱、小颌畸形、垂腕、后肢旋转不良、尾巴弯曲、驼背、心脏异位。本文将由4部分组成，分别论述器官系统异常、骨骼异常以及致跛化合物的作用机制。
