Meller S M, De Paola D P, Barton L H, Mandella R D
Anat Rec. 1980 Oct;198(2):229-44. doi: 10.1002/ar.1091980210.
Examination of surface topography in prefusion stages of secondary palatal development in rabbit embryos reveals a sequence of alterations in the surface cells of the epithelium along the medial margins of the palatal processes. A progressive increase in cellular protrusions resembling lamellipodia and filopodia, as well as cellular necrosis, is observed in those areas that undergo fusion. The changes precede fusion and are restricted to fusion sites. Prior to and at the time of epithelial contact between palatal processes, many long slender cellular protrusions are seen bridging the gap between the approximating tissues. The localization of the epithelial alterations and the appearance of similar cellular morphology in other embryonic epithelial fusion events strongly suggest: either an active role of the epithelial cells in the fusion of the secondary palate, or some common fundamental biochemical events that may facilitate or are responsible for the initial adhesion of such tissues.
对兔胚胎继发腭发育预融合阶段的表面形貌检查显示，沿着腭突内侧边缘的上皮表面细胞发生了一系列变化。在那些发生融合的区域，观察到类似片状伪足和丝状伪足的细胞突起以及细胞坏死逐渐增加。这些变化先于融合且局限于融合部位。在腭突上皮接触之前及接触时，可见许多细长的细胞突起连接着接近组织之间的间隙。上皮变化的定位以及在其他胚胎上皮融合事件中出现的类似细胞形态强烈表明：要么上皮细胞在继发腭融合中起积极作用，要么存在一些共同的基本生化事件，可能促进或导致此类组织的初始黏附。
