Baker N F, Fisk R A
Am J Vet Res. 1980 Nov;41(11):1854-6.
Controlled trials were conducted to evaluate the anthelmintic action of haloxon in 2 phenotypes of lambs, 1 having an A esterase in plasma which rapidly hydrolyzes di-(2-chloroethyl)aryl phosphates and the other without this enzyme. A total of 116 lambs, 57 with and 59 without the plasma A esterase, 6 to 9 months old, harboring naturally acquired nematode infections were used in 3 trials. Haloxon was administered orally at 20, 25, and 35 mg/kg of body weight. Nematodes against which haloxon was evaluated in the abomasum were Ostertagia circumcincta and Trichostrongylus axei and in the small intestine were T vitrinus, T colubriformis, Nematodirus spathiger, and N filicollis. The anthelmintic efficiency of haloxon did not differ in the 2 phenotypes of sheep.
进行了对照试验，以评估哈罗松对两种表型羔羊的驱虫作用，一种表型的羔羊血浆中有A酯酶，能迅速水解二（2-氯乙基）芳基磷酸酯，另一种表型的羔羊则没有这种酶。共有116只6至9个月大、自然感染线虫的羔羊用于3项试验，其中57只血浆中有A酯酶，59只没有。哈罗松按20、25和35毫克/千克体重口服给药。在真胃中评估哈罗松驱虫效果的线虫有环形奥斯特他线虫和艾氏毛圆线虫，在小肠中评估的线虫有玻璃细颈线虫、蛇形毛圆线虫、斯氏细颈线虫和丝状细颈线虫。哈罗松对两种表型绵羊的驱虫效果没有差异。
