Jacobs R M, Valli V E, Wilkie B N
Am J Vet Res. 1980 Dec;41(12):1942-6.
Changes in the serum electrophoretic patterns and immunoglobulin (Ig) concentrations were examined in cows with lymphoma, in clinically normal cows, and in cows with various inflammatory conditions. Cows with lymphoma had moderately increased concentrations of alpha 2-globulin which were significantly different from concentrations in normal animals (P less than or equal to 0.01) and in animals with inflammatory conditions (P less than or equal to 0.05). This was possibly due to the increase in acute-phase reactant proteins which occurs with inflammation and neoplasia; however, there was the suggestion that these alpha 2-globulins may be qualitatively different in animals with neoplasia. beta 2-Globulins were significantly (P less than or equal to 0.01) decreased in cows with lymphoma, and this was attributed to lower concentrations of Ig observed in this group. All Ig classes, except IgA, were decreased in cows with lymphoma, but the greatest decrease was observed in the IgM class.
对患有淋巴瘤的奶牛、临床正常的奶牛以及患有各种炎症的奶牛的血清电泳图谱和免疫球蛋白（Ig）浓度变化进行了检测。患有淋巴瘤的奶牛α2球蛋白浓度适度升高，与正常动物（P≤0.01）和患有炎症的动物（P≤0.05）的浓度存在显著差异。这可能是由于炎症和肿瘤形成时急性期反应蛋白增加所致；然而，有迹象表明，这些α2球蛋白在患有肿瘤的动物中可能在质量上有所不同。患有淋巴瘤的奶牛β2球蛋白显著降低（P≤0.01），这归因于该组中观察到的Ig浓度较低。除IgA外，患有淋巴瘤的奶牛所有Ig类别均降低，但IgM类别的降低最为明显。
