Parhad I M, Johnson K P, Wolinsky J S, Swoveland P
Ann Neurol. 1981 Jan;9(1):21-7. doi: 10.1002/ana.410090105.
A neuroadapted strain of measles virus (HNT) was administered by inhalation to newborn hamsters. Primary replication of virus in the lung was followed by the transient appearance of virus in spleen within 7 to 9 days of inoculation. A terminal encephalitis occurred between 6 and 60 days in 31% of infected hamsters, and virus was recovered by explant culture of these brains. Virus could not be cultured directly from brain or tissue homogenates. At least 7% of hamsters that had survived the infection for two months had antibody to measles virus. The histopathological change in morbid animals was limited to the central nervous system (CNS) and consisted of small foci of necrosis, perivascular mononuclear cell infiltrates, intracytoplasmic and intranuclear inclusions, and vacuolated pyknotic neurons. Immunofluorescent studies disclosed measles antigen in the lungs and brain. This hamster model of measles encephalitis following a "natural" route of inoculation appears to represent a faithful reproduction of certain CNS complications of natural measles infection in humans, i.e., measles encephalitis and subacute sclerosing panencephalitis.
通过吸入方式给新生仓鼠接种一种神经适应株麻疹病毒（HNT）。病毒在肺内进行初次复制，接种后7至9天内脾脏中短暂出现病毒。31%的受感染仓鼠在6至60天之间发生了终末期脑炎，通过对这些脑部进行外植体培养可分离出病毒。病毒无法直接从脑或组织匀浆中培养出来。至少7%在感染中存活两个月的仓鼠具有抗麻疹病毒抗体。患病动物的组织病理学变化仅限于中枢神经系统（CNS），包括小坏死灶、血管周围单核细胞浸润、胞浆内和核内包涵体以及空泡化固缩神经元。免疫荧光研究显示肺和脑中存在麻疹抗原。这种通过“自然”接种途径建立的仓鼠麻疹脑炎模型似乎忠实地再现了人类自然麻疹感染的某些中枢神经系统并发症，即麻疹脑炎和亚急性硬化性全脑炎。
