Thormar H, Mehta P D, Barshatzky M R, Brown H R
Lab Anim Sci. 1985 Jun;35(3):229-32.
Young adult ferrets were used as experimental animals to study subacute sclerosing panencephalitis (SSPE). When cells infected with cell-associated measles virus strains isolated from SSPE patients were inoculated intracerebrally (i.c.) into ferrets, they developed an acute encephalitis and died within 1 to 3 weeks without detectable antibody formation. Immunization with live measles vaccine 5 weeks before i.c. inoculation changed the course of the infection in about 50% of the ferrets. These animals developed a subacute encephalitis within weeks or months after inoculation. Cell-associated measles virus was isolated from their brains and high measles antibody titers were found in their sera, comparable to those in sera of SSPE patients. Measles virus specific immunoglobulins (IgG) were present in their brains and determination of IgG/albumin ratios indicated that antibodies were synthesized in the brain in response to the persistent measles virus infection. Measles specific oligoclonal IgG bands were found in the sera and spinal fluids of these animals. Therefore, subacute ferret encephalitis has virological and immunological characteristics in common with SSPE, indicating that it may serve as a model for the human disease. Other animal models of SSPE are described briefly.
年轻成年雪貂被用作实验动物来研究亚急性硬化性全脑炎（SSPE）。当将感染了从SSPE患者分离出的细胞相关麻疹病毒株的细胞脑内接种到雪貂体内时，它们会发生急性脑炎，并在1至3周内死亡，且未检测到抗体形成。在脑内接种前5周用活麻疹疫苗免疫，改变了约50%雪貂的感染进程。这些动物在接种后数周或数月内发生亚急性脑炎。从它们的脑中分离出细胞相关麻疹病毒，并且在它们的血清中发现了高麻疹抗体滴度，这与SSPE患者血清中的滴度相当。它们的脑中存在麻疹病毒特异性免疫球蛋白（IgG），IgG/白蛋白比率的测定表明，针对持续的麻疹病毒感染，脑内合成了抗体。在这些动物的血清和脑脊液中发现了麻疹特异性寡克隆IgG条带。因此，亚急性雪貂脑炎具有与SSPE相同的病毒学和免疫学特征，表明它可能作为人类疾病的一个模型。简要描述了SSPE的其他动物模型。
