Francavilla S, Moscardelli S, Francavilla F, Casasanta N, Properzi G, Martini M, Santiemma V
Arch Androl. 1981 Feb;6(1):1-11. doi: 10.3109/01485018108987340.
The changes resulting from treatment with cadmium were studied following the histological changes, the modification of both vascular permeability to vital dyes and of alkaline phosphatase activity in rat testis and epididymis. The testicular extravasation of acriflavine started 90 min following parenteral injection of cadmium and increased thereafter synchronous with an increase in testicular and epididymal weights due to edema. At 14 and 24 hr a striking decrease of interstitial fluorescence and tubular degeneration were noted in testis and caput epididymis due to thrombosis of the microvascular circulation. The barrier noted at 8 hr following cadmium injection. No changes of alkaline phosphatase activity was detected in testicular and epididymal blood vessels after cadmium injection. Previous treatment with cyproterone acetate accelerated the appearance of such alterations. The interstitial nuclear staining with acriflavine appeared in the testis at 1 hr and was diffuse at 90 and 120 min. cyproterone acetate seemed to accelerate the appearance of tubular degeneration at 8 hr after cadmium injection. The changes of the male rat gonad following cadmium treatment were characterized by an increased vascular permeability and generalized thrombosis. An inbalance of androgen stimulation seems to increase the blood vessels susceptibility to cadmium.
通过组织学变化、大鼠睾丸和附睾中血管对活性染料的通透性变化以及碱性磷酸酶活性变化，研究了镉处理所导致的改变。腹腔注射镉后90分钟，吖啶黄在睾丸的外渗开始，并随着因水肿导致的睾丸和附睾重量增加而同步增加。在14小时和24小时时，由于微血管循环血栓形成，在睾丸和附睾头部观察到间质荧光显著降低和小管变性。镉注射后8小时出现屏障。镉注射后，在睾丸和附睾血管中未检测到碱性磷酸酶活性变化。先前用醋酸环丙孕酮处理加速了此类改变的出现。吖啶黄间质核染色在睾丸中1小时出现，在90分钟和120分钟时呈弥漫性。醋酸环丙孕酮似乎在镉注射后8小时加速了小管变性的出现。镉处理后雄性大鼠性腺的变化特征为血管通透性增加和全身性血栓形成。雄激素刺激失衡似乎增加了血管对镉的易感性。
