Guerra F, Rey de Viñas J L, Ortega R
Arch Inst Cardiol Mex. 1981 Jan-Feb;51(1):3-12.
During the induction of myocardial infarction in the rat by isoproterenol, a decrease in the voltage of the T wave in the electrocardiogram is produced, which reflects myocardial ischemia through a previous infusion of a KCl solution; while the perfusion of NaCl increases the voltage of such wave and therefore cardiac ischemia. The values of free Pi in the myocardium increase significantly with the administration of isoproterenol. If KCl has been perfused previously, the figures of free Pi are superior in 155% of those obtained with the perfusion of NaCl. The values of all the energetic phosphates, AMP, ADP and ATP decrease inversely and in a significant way with isoproterenol and the perfusion of NaCl and KCl. The activity of creatine-phosphokinase in the myocardium decreases with isoproterenol, specially with the previous perfusion of KCl Similarly, the activity of the isoenzimes of lactic dehydrogenase L1 and L2 (alpha-HBDH), decreases, which intensifies with previous perfusion of NaCl, but diminishes with KCl. The activity of malicodehydrogenase (MDH) in the myocardium decreases with isoproterenol, even with the previous perfusion of NaCl, but in lesser degree than with KCl.
在用异丙肾上腺素诱导大鼠心肌梗死的过程中，心电图T波电压会降低，这通过预先输注氯化钾溶液反映心肌缺血；而灌注氯化钠会增加该波的电压，从而导致心脏缺血。心肌中游离无机磷的值在给予异丙肾上腺素后显著增加。如果先前已灌注氯化钾，游离无机磷的值比灌注氯化钠时获得的值高155%。所有高能磷酸盐、AMP、ADP和ATP的值与异丙肾上腺素以及氯化钠和氯化钾的灌注呈反比且显著下降。心肌中肌酸磷酸激酶的活性随异丙肾上腺素而降低，特别是在先前灌注氯化钾的情况下。同样，乳酸脱氢酶L1和L2（α - HBDH）同工酶的活性降低，在先前灌注氯化钠时会加剧，但在灌注氯化钾时会减弱。心肌中苹果酸脱氢酶（MDH）的活性随异丙肾上腺素而降低，即使在先前灌注氯化钠的情况下也是如此，但程度小于灌注氯化钾时。
