Haynes B F, Pikus A, Kaiser-Kupfer M, Fauci A S
Arthritis Rheum. 1981 Mar;24(3):501-3. doi: 10.1002/art.1780240308.
Cogan's syndrome (CS) is the association of acute nonsyphilitic interstitial keratitis and acute episodes of vertigo, tinnitus, and hearing loss. We have prospectively followed 6 patients with CS who were treated within 4 weeks after the acute onset of hearing loss. Within 1 to 2 weeks after the initiation of corticosteroid therapy, all 6 patients demonstrated improved hearing thresholds for pure tones and supra-threshold speech discrimination results. These patients have been followed an average of 2.5 years (range 0.25-9 years); all have only mild to moderate hearing impairment in the mid (1,000 to 2,000 Hz) and low (250 to 500 Hz) frequency sound ranges. Three of the patients have been tapered off steroids completely with no subsequent permanent decrement of hearing. Thus, early oral corticosteroid administration to patients with sudden hearing loss associated with Cogan's syndrome may preserve auditory function.
科根综合征（CS）是急性非梅毒性间质性角膜炎与眩晕、耳鸣及听力损失急性发作的关联。我们前瞻性地随访了6例在听力损失急性发作后4周内接受治疗的CS患者。在开始皮质类固醇治疗后的1至2周内，所有6例患者的纯音听力阈值均有所改善，超阈值言语辨别结果也有所改善。这些患者平均随访了2.5年（范围为0.25至9年）；所有人在中（1000至2000赫兹）和低（250至500赫兹）频率声音范围内仅有轻度至中度听力障碍。其中3例患者已完全停用类固醇，听力无后续永久性下降。因此，对与科根综合征相关的突发听力损失患者早期口服皮质类固醇可能会保留听觉功能。
