Fine Sean, Nee Judy, Thakuria Pranjal, Duff Brian, Farraye Francis A, Shah Samir A
Alpert Medical School, Brown University, Rhode Island Hospital, Providence, RI, USA.
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Dig Dis Sci. 2017 Dec;62(12):3269-3279. doi: 10.1007/s10620-017-4781-x. Epub 2017 Oct 24.
Inflammatory bowel disease (IBD) is primarily a disease of the gastrointestinal tract, though it can often affect other organ systems. These extraintestinal manifestations occur in a quarter to one-third of patients with Crohn's disease and ulcerative colitis. While musculoskeletal and dermatologic manifestations are the most common, it is also important to be cognizant of head, eye, ear, nose, and throat (HEENT) manifestations and educate IBD patients about them. Here we review the ocular manifestations in conjunction with the lesser-known but increasingly recognized ENT manifestations. Considering the lack of randomized controlled trials in treating HEENT manifestations of IBD, this review is primarily based on case reports, case series, and expert opinion with a particular focus on the newer literature supporting use of anti-TNF agents.
炎症性肠病（IBD）主要是一种胃肠道疾病，不过它常常会影响其他器官系统。这些肠外表现出现在四分之一至三分之一的克罗恩病和溃疡性结肠炎患者中。虽然肌肉骨骼和皮肤表现最为常见，但认识到头、眼、耳、鼻、喉（HEENT）的表现并对IBD患者进行相关教育也很重要。在此，我们结合鲜为人知但日益受到认可的耳鼻喉科表现来回顾眼部表现。鉴于在治疗IBD的HEENT表现方面缺乏随机对照试验，本综述主要基于病例报告、病例系列以及专家意见，特别关注支持使用抗TNF药物的最新文献。
