Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. II - Phospholipids.

Effect of partial hepatectomy and administration of actinomycin D to partially hepatectomized dogs was studied on the amounts of serum and betalipoprotein phospholipids and incorporation of NaH2 32PO4 into various phospholipid at various periods after surgery. Partial hepatectomy generally did not affect the amounts of various phospholipids as compared to the sham operated controls, though the values in experimental dogs were lower than the control. Actinomycin D did not affect serum and betalipoprotein phospholipids as compared to the sham operated controls. Partial hepatectomy reduced the incorporation of NaH2 32PO4 into all phospholipid components of serum and betalipoprotein as compared to sham operated controls. However, administration of actinomycin D to partially hepatectomized dogs stimulated the incorporation of NaH2 32PO4 into all serum and betalipoprotein phospholipid components, being more prominent in the case of lysophosphatidyl-choline as compared to the partially hepatectomized dogs.