Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. III - Fatty acid distribution.

Effect of administration of actinomycin D to partially hepatectomized dogs has been studied on various neutral and phospholipid components of serum and its beta-lipoprotein fraction. Partial hepatectomy altered distribution of palmitic, stearic, oleic, linoleic and arachidonic acid in various components of neutral lipids and phospholipids of serum and its dextran sulphate precipitable fraction. Administration of actinomycin D to partially hepatectomized dogs reduced the levels of stearic acid and linoleic acid and increased that of oleic acid in triglyceride component; reduced the levels of oleic and linoleic acids in esterified cholesterol; raised the levels of stearic acid of phosphatidyl choline and reduced the levels of linoleic and palmitic acid of lysophosphatidyl choline.