大鼠肝脏铁蛋白翻译后修饰的证据。
Evidence for post-translational changes in rat liver ferritin.
作者信息
Treffry A, Harrison P M
出版信息
Biochim Biophys Acta. 1980 Dec 11;610(2):421-4. doi: 10.1016/0005-2787(80)90023-4.
PMID:7213634
Abstract
Analysis of rat liver isoferritins labelled by NaH14CO3 injection shows that acidic isoferritins decay exponentially, while activity in more basic isoferritins rises over 2-3 days. This suggests that isoferritins of low pI become more basic by post-translational modification, occurring over the whole life time of the protein.
摘要
通过注射NaH14CO3标记大鼠肝脏铁蛋白异构体的分析表明，酸性铁蛋白异构体呈指数衰减，而碱性更强的铁蛋白异构体的活性在2 - 3天内升高。这表明低pI的铁蛋白异构体通过翻译后修饰变得更具碱性，这种修饰发生在蛋白质的整个生命周期。
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