磷酸烯醇丙酮酸类似物对烯醇丙酮酸转移酶活性的影响以及尿苷二磷酸-N-乙酰葡糖胺对活性位点SH基团反应性的影响。
Effect of phosphoenolpyruvate analogs on the activity of enoylpyruvate transferase and the effect of UDP-N-acetylglucosamine on the reactivity of the active site SH group.
作者信息
Anwar R A, Vlaovic M
出版信息
Biochim Biophys Acta. 1980 Dec 4;616(2):389-94. doi: 10.1016/0005-2744(80)90157-6.
Effect of several phosphoenolpyruvate analogs on the activity of enoylpyruvate (phosphoenolpyruvate: UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase, EC 2.5.1.7) transferase was examined. The results suggest that the phosphoenolpyruvate binding site of the transferase is very similar to that of pyruvate kinase (ATP: pyruvate 2-O-phosphotransferase, EC 2.7.1.40). Evidence is presented to show that the binding of UDP-GlcNAc to the transferase enhances the reactivity of the active site SH group.
研究了几种磷酸烯醇丙酮酸类似物对烯酰丙酮酸（磷酸烯醇丙酮酸：UDP-2-乙酰氨基-2-脱氧-D-葡萄糖2-烯酰-1-羧乙基转移酶，EC 2.5.1.7）转移酶活性的影响。结果表明，该转移酶的磷酸烯醇丙酮酸结合位点与丙酮酸激酶（ATP：丙酮酸2-O-磷酸转移酶，EC 2.7.1.40）的结合位点非常相似。有证据表明，UDP-GlcNAc与转移酶的结合增强了活性位点SH基团的反应性。
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