Palo J, Duchesne J, Wikström J
J Neurol. 1977 Oct 7;216(3):217-22. doi: 10.1007/BF00313623.
The frequency of malignant diseases among 1866 living and 340 deceased multiple sclerosis (MS) patients was investigated in Finland. The study revealed a low prevalence (0.64%) and mortality (0.07%) rate of cancer among MS patients. The difference between MS patients and general population was significant. The highest rate was found in the group from 40 to 49 years while in the general population the rate of cancer among MS patients tended to fall after the age of 50. The possible role of selenium, one of the antioxidants in the pathogenesis of MS and cancer, is discussed because recent data have shown a very high negative correlation between selenium and cancer death rates.
在芬兰，对1866名在世的和340名已故的多发性硬化症（MS）患者中的恶性疾病发生率进行了调查。研究显示，MS患者中癌症的患病率（0.64%）和死亡率（0.07%）较低。MS患者与普通人群之间的差异显著。40至49岁组的发生率最高，而在普通人群中，MS患者的癌症发生率在50岁以后趋于下降。由于最近的数据显示硒与癌症死亡率之间存在非常高的负相关性，因此讨论了抗氧化剂之一的硒在MS和癌症发病机制中的可能作用。
