Mirzoian S A, Bekian R S
Biull Eksp Biol Med. 1981;91(1):50-1.
Nicotinamide adenine dinucleotide (NAD) decreases the resistance of cerebral vessels and increases the local (hydrogen clearance) and regional (133Xe clearance) cortical blood flow in intact cats. In cerebral blood flow deficiency the level of ammonia in brain tissue is appreciably increased. Favouring normalization of the deranged cerebral blood flow NAD neutralizes excess ammonia by means of glutamate dehydrogenase activity recovery in the reduction amination reaction. This indicates that NAD influences the neurochemical mechanisms of compensatory regulation of the cerebral blood flow.
烟酰胺腺嘌呤二核苷酸（NAD）可降低完整猫脑血管的阻力，并增加局部（氢清除率）和区域（氙133清除率）皮质血流量。在脑血流量不足时，脑组织中的氨水平会明显升高。NAD有助于紊乱的脑血流量恢复正常，通过还原胺化反应中谷氨酸脱氢酶活性的恢复来中和过量的氨。这表明NAD影响脑血流量代偿调节的神经化学机制。
