Mirzoian S A, Bekian R S
Biull Eksp Biol Med. 1979 Nov;88(11):572-4.
In cerebral blood flow deficiency the level of ammonia in the cerebral tissue is appreciably increased and the activity of glutamate dehydrogenase (GDH) is decreased without material variations in the content of glutamine and amide groups of protein. Favouring normalization of the deranged cerebral blood flow, euphylline neutralizes excess ammonia by means of GDH activity recovery in the reduction amination reaction. The drug exhibited the most pronounced effect during acute cerebral ischemia. This indicates that euphylline influences the neurochemical mechanisms of the compensatory regulation of cerebral blood flow.
在脑血流量不足时，脑组织中的氨水平明显升高，谷氨酸脱氢酶（GDH）的活性降低，而谷氨酰胺和蛋白质酰胺基团的含量没有实质性变化。通过恢复还原胺化反应中的GDH活性，氨茶碱有助于紊乱的脑血流量恢复正常，从而中和过量的氨。该药物在急性脑缺血期间表现出最显著的效果。这表明氨茶碱影响脑血流量代偿调节的神经化学机制。
