大鼠体内的立体特异性右啡烷耐受性

Stereospecific dextrorphan tolerance in rats.

作者信息

Carney J M, Sirochman V L

出版信息

Br J Pharmacol. 1981 Feb;72(2):245-6. doi: 10.1111/j.1476-5381.1981.tb09120.x.

DOI:10.1111/j.1476-5381.1981.tb09120.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071512/

Abstract

1 Levorphanol was 20 times more potent than dextrorphan in decreasing food-reinforced fixed ratio 15 responding in male Sprague Dawley rats. 2 Chronic dextrorphan (100 mg/kg, i.p.; every 8 h) resulted in the development of dextrorphan tolerance. The dextrorphan dose-effect curve was shifted to the right three fold. 3 In contrast to dextrorphan, nontolerance developed to the effects of levorphanol. 4 These data support the hypothesis that (+)-isomers of opioids produce pharmacologically distinct CNS effects.

摘要

1 左啡诺在降低雄性斯普拉格-道利大鼠食物强化固定比率15反应方面的效力比右啡烷强20倍。2 慢性给予右啡烷（100毫克/千克，腹腔注射；每8小时一次）导致右啡烷耐受性的产生。右啡烷的剂量-效应曲线向右移动了三倍。3 与右啡烷相反，左啡诺的作用未产生耐受性。4 这些数据支持了阿片类药物的（+）-异构体产生药理学上不同的中枢神经系统效应这一假说。

相似文献

1

Stereospecific dextrorphan tolerance in rats.大鼠体内的立体特异性右啡烷耐受性

Br J Pharmacol. 1981 Feb;72(2):245-6. doi: 10.1111/j.1476-5381.1981.tb09120.x.

2

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3

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Discriminative stimulus effects of dextrorphan in pigeons.右啡烷对鸽子的辨别性刺激作用。

J Pharmacol Exp Ther. 1983 Dec;227(3):723-31.

本文引用的文献

1

Actions and addiction liabilities of dromoran derivatives in man.屈大麻酚衍生物对人体的作用及成瘾倾向

J Pharmacol Exp Ther. 1953 Apr;107(4):524-30.

2

Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: evidence for a new class of receptors?（+）-和（-）-吗啡的立体特异性和非立体特异性作用：一类新受体的证据？

Science. 1977 Nov 25;198(4319):842-5. doi: 10.1126/science.199942.

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