Tolis G, Mehta A, Harvey C, Andermann E, Andermann F, Barbeau A
Can J Neurol Sci. 1980 Nov;7(4):401-3. doi: 10.1017/s0317167100022940.
Homozygotes, obligatory heterozygotes and potential carriers of the Friedreich's Ataxia gene were tested with an oral glucose tolerance in order to assess a. the prevalence of abnormalities in glucose handling, b. the secretory pattern of two "diabetogenic" hormones, growth hormones and prolactin and c. to evaluate the possibility for detection of an abnormal trend in these hormones to be used as a genetic marker. Despite the high prevalence of glucose abnormalities horizontally and vertically in these families, the basal output and responses of these metabolic hormones to a glucose challenge were appropriate and thus not characteristic of any of the above groups.
对弗里德赖希共济失调基因的纯合子、必然杂合子和潜在携带者进行了口服葡萄糖耐量测试，以评估：a. 葡萄糖处理异常的患病率；b. 两种“致糖尿病”激素（生长激素和催乳素）的分泌模式；c. 评估检测这些激素异常趋势以用作遗传标记的可能性。尽管在这些家族中葡萄糖异常在横向和纵向的患病率都很高，但这些代谢激素的基础分泌量以及对葡萄糖刺激的反应都是正常的，因此不属于上述任何一组的特征。
