Tolis G, Mehta A, Andermann E, Harvey C, Barbeau A
Can J Neurol Sci. 1982 May;9(2):189-90. doi: 10.1017/s0317167100043948.
Oral glucose tolerance, thyroid function tests, as well as thyrotropin, prolactin and growth hormone release after administration of thyrotropin releasing hormone, were evaluated in patients with Friedreich's ataxia and unaffected family members. Impaired glucose tolerance was found in the majority of family members, affected or not. Thyroid hormone levels and PRL and TSH responses to TRH, were similar in all and normal. However, GH responses to TRH were abnormal in half of the patients, but in none of the unaffected family members. Paradoxical responses to neuropeptides may characterize some Friedreich's ataxia patients, and may predict the possibility of therapeutic maneuvers with such peptides in these patients.
对弗里德赖希共济失调患者及其未患病的家庭成员进行了口服葡萄糖耐量试验、甲状腺功能测试，以及注射促甲状腺激素释放激素后的促甲状腺激素、催乳素和生长激素释放情况评估。在大多数家庭成员中，无论是否患病，均发现葡萄糖耐量受损。所有人的甲状腺激素水平以及催乳素和促甲状腺激素对促甲状腺激素释放激素的反应均相似且正常。然而，一半的患者对促甲状腺激素释放激素的生长激素反应异常，但未患病的家庭成员均无此异常。对神经肽的反常反应可能是一些弗里德赖希共济失调患者的特征，并且可能预示着在这些患者中使用此类肽进行治疗的可能性。
