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弗里德赖希共济失调中的糖化血红蛋白

Glycosylated hemoglobins in Friedreich's ataxia.

作者信息

Draper P, Shapcott D, Langlois M, Lemieux B

出版信息

Can J Neurol Sci. 1980 Nov;7(4):405-7. doi: 10.1017/s0317167100022952.

DOI:10.1017/s0317167100022952
PMID:7214255
Abstract

In a study of glycosylated hemoglobins in Friedreich's Ataxia patients and in family members, the level was found to be higher in insulin dependent diabetics than in healthy non-diabetic control subjects (p < 0.01), but was similar to non-ataxic diabetic control subjects. Results for non-diabetic Friedreich's Ataxia patients and siblings were similar to those for non-diabetic control subjects while levels were slightly increased in the heterozygotes. It is concluded that in Friedreich's Ataxia patients and family members (apart from the insulin dependent diabetics), there was no hyperglycemia sufficient to be detected as an increase in glycosylated hemoglobins.

摘要

在一项针对弗里德赖希共济失调患者及其家庭成员糖化血红蛋白的研究中,发现胰岛素依赖型糖尿病患者的糖化血红蛋白水平高于健康非糖尿病对照受试者(p < 0.01),但与非共济失调糖尿病对照受试者相似。非糖尿病弗里德赖希共济失调患者及其兄弟姐妹的结果与非糖尿病对照受试者相似,而杂合子的水平略有升高。得出的结论是,在弗里德赖希共济失调患者及其家庭成员(不包括胰岛素依赖型糖尿病患者)中,不存在足以通过糖化血红蛋白升高检测到的高血糖症。

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1
Glycosylated hemoglobins in Friedreich's ataxia.弗里德赖希共济失调中的糖化血红蛋白
Can J Neurol Sci. 1980 Nov;7(4):405-7. doi: 10.1017/s0317167100022952.
2
Glucose tolerance and erythrocyte insulin receptors in Friedreich's ataxia.弗里德赖希共济失调中的葡萄糖耐量和红细胞胰岛素受体
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Friedreich's ataxia and oral glucose tolerance: I. The effect of ingested glucose on serum glucose and insulin values in homozygotes, obligate heterozygotes and potential carriers of the Friedreich's ataxia gene.弗里德赖希共济失调与口服葡萄糖耐量:I. 摄入葡萄糖对弗里德赖希共济失调基因纯合子、必然杂合子和潜在携带者血清葡萄糖及胰岛素值的影响。
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Erythrocyte membrane lipids in Friedreich's ataxia.弗里德赖希共济失调中的红细胞膜脂质
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A family with pseudodominant Friedreich's ataxia showing marked variation of phenotype between affected siblings.一个呈现假显性遗传性共济失调的家族,受累兄弟姐妹之间表现出明显的表型差异。
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Glucose and insulin metabolism in Friedreich's ataxia.弗里德赖希共济失调中的葡萄糖与胰岛素代谢
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[Erythrocyte deformability and glycosylated hemoglobins in diabetics].[糖尿病患者的红细胞变形性与糖化血红蛋白]
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Pseudodominant Friedreich's ataxia with phenotypic heterogeneity.具有表型异质性的假显性弗里德赖希共济失调
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