弗里德赖希共济失调中的红细胞膜脂质

Erythrocyte membrane lipids in Friedreich's ataxia.

作者信息

Draper P, Huang Y S, Shapcott D, Lemieux B, Brennan M, Barbeau A, Davignon J

出版信息

Can J Neurol Sci. 1979 May;6(2):291-4. doi: 10.1017/s0317167100119791.

DOI:10.1017/s0317167100119791

Abstract

In a study of the lipid composition of erythrocyte membranes in Friedreich's ataxia, the concentration of the major membrane components (phospholipids, cholesterol and protein) in ataxic patients, family members, and control subjects were found to be the same. The total fatty acid distribution was also normal. However, an altered distribution of phospholipid classes in erythrocytes was noted (an increase of PI + PS and a decrease of PE in Friedreich's ataxia patients).

摘要

在一项关于弗里德赖希共济失调患者红细胞膜脂质组成的研究中，发现共济失调患者、其家庭成员和对照受试者的主要膜成分（磷脂、胆固醇和蛋白质）浓度相同。总脂肪酸分布也正常。然而，注意到红细胞中磷脂类的分布发生了改变（弗里德赖希共济失调患者中磷脂酰肌醇+磷脂酰丝氨酸增加，磷脂酰乙醇胺减少）。