Soloway M S, Masters S
Cancer. 1980 Sep 1;46(5):1158-63. doi: 10.1002/1097-0142(19800901)46:5<1158::aid-cncr2820460514>3.0.co;2-e.
In an effort to determine whether transitional tumor cells will preferentially implant on the cauterized urothelial surface, a reproducible technique for cauterization of a portion of the murine bladder was established. This technique simulated a transurethral fulguration of a bladder tumor in humans. Transplantable tumor cells (1 X 10(6)) were placed transurethrally into the bladder of 50 mice. Twenty-five of these mice each had a portion of their bladder cauterized prior to insertion of tumor cells. Implantation with subsequent tumors occurred in 54% of mice with cauterization, in contrast to 12% of mice with an intact urothelial surface (P less than 0.005). Intravesical thio-tepa, mitomycin C, and cis-platinum were capable of significantly reducing the incidence of implantation. These results suggest that seeding may be a contributing factor to the high recurrence rate following endoscopic resection or fulguration of bladder tumors and that intravesical chemotherapy initiated shortly after surgery may reduce the incidence of implantation.
为了确定移行性肿瘤细胞是否会优先种植在烧灼的尿路上皮表面，建立了一种可重复的烧灼小鼠部分膀胱的技术。该技术模拟了人类膀胱肿瘤的经尿道电灼术。将可移植肿瘤细胞（1×10⁶）经尿道植入50只小鼠的膀胱。其中25只小鼠在植入肿瘤细胞前，其膀胱的一部分被烧灼。烧灼组小鼠后续发生肿瘤种植的比例为54%，而尿路上皮表面完整的小鼠为12%（P<0.005）。膀胱内注射噻替哌、丝裂霉素C和顺铂能够显著降低种植发生率。这些结果表明，种植可能是膀胱肿瘤内镜切除或电灼术后高复发率的一个促成因素，并且术后不久开始的膀胱内化疗可能会降低种植发生率。
