Travis E L, Reinartz G, Chu A M, Down J D, Fowler J F
Cancer Res. 1981 May;41(5):1803-7.
A spontaneous metastases model in mice is being used to test the efficiency of various treatments in eliminating metastases. Solid tumors were transplanted into the tails of mice and removed by tail transection when they had grown to a 4- to 5- or 6- to 7-mm mean diameter. Subsequently, 70 to 95% of mice not given other treatment developed metastases in the lungs or in regional lymph nodes (lumbar sacral region), or in both sites. The present paper reports the effects of whole-body or partial-body treatment on these metastases. The treatments, which started at the time of surgical transection of the tail, included a range of single or fractionated doses of cyclophosphamide (CTX) or X-rays given either to the whole body or locally to the lungs only. CTX reduced the incidence of metastases in both sites although the incidence of lung metastases was reduced by smaller doses of CTX than that of the lumbar sacral metastases. Whole-body irradiation of 6 grays (600 rads) had no effect on the incidence of metastases, whereas local irradiation of the lungs with single doses of 14.5 or 20 grays reduced the number substantially, as did 95 mg or more of CTX per kg. Thus, CTX or radiation reduced the incidence of lung metastases in a system where metastases developed from cells seeded from a primary tumor rather than from a cell suspension injected into the tail vein.
一种小鼠自发性转移模型正被用于测试各种治疗方法在消除转移方面的效率。将实体瘤移植到小鼠尾部，当肿瘤平均直径长到4至5毫米或6至7毫米时，通过截断尾巴将其切除。随后，70%至95%未接受其他治疗的小鼠在肺部或区域淋巴结（腰骶部）或这两个部位发生转移。本文报告了全身或局部治疗对这些转移的影响。治疗从截断尾巴时开始，包括一系列单次或分次剂量的环磷酰胺（CTX）或X射线，分别给予全身或仅局部照射肺部。CTX降低了两个部位转移的发生率，尽管降低肺部转移发生率所需的CTX剂量比降低腰骶部转移发生率的剂量小。6戈瑞（600拉德）的全身照射对转移发生率没有影响，而单次剂量14.5或20戈瑞的肺部局部照射则显著减少了转移数量，每千克95毫克或更多的CTX也有同样效果。因此，在一个转移是由原发肿瘤播散的细胞而非注入尾静脉的细胞悬液形成的系统中，CTX或放疗降低了肺部转移的发生率。
