Stein H, Bab I A, Sela J
Cell Tissue Res. 1981;214(3):449-54. doi: 10.1007/BF00233487.
Free autologous grafts of synovial tissue were transplanted into experimental defects produced in the articular cartilage of rabbit knee joints. The grafted tissue underwent transformation into fibrocartilage. Extracellular matrix vesicles associated with calcified areas were present at the grafted sites. Hydroxyapatite crystals were found within these vesicles and in their vicinity. No calcification occurred in articular cartilage from sham operated joints in which defects were produced but no grafts made and in normal controls. These tissues showed abundant matrix vesicles devoid of crystalline mineral. A careful study of normal synovial tissue did not reveal matrix vesicles and calcifications. The present observations suggest that matrix vesicles in normal articular cartilage exist in a latent form. Vesicle mineralization following surgical manipulations of the joint is probably a manifestation of the metabolic stage of the tissue.
将自体滑膜组织游离移植到兔膝关节软骨的实验性缺损处。移植组织转变为纤维软骨。移植部位出现了与钙化区域相关的细胞外基质小泡。在这些小泡及其附近发现了羟基磷灰石晶体。在假手术关节的关节软骨中未发生钙化，这些关节制造了缺损但未进行移植，正常对照组也未发生钙化。这些组织显示有丰富的无晶体矿物质的基质小泡。对正常滑膜组织的仔细研究未发现基质小泡和钙化。目前的观察结果表明，正常关节软骨中的基质小泡以潜伏形式存在。关节手术操作后的小泡矿化可能是组织代谢阶段的一种表现。
