Lifshitz R, Parhami B, Mozes E
Eur J Immunol. 1981 Jan;11(1):27-31. doi: 10.1002/eji.1830110107.
Murine anti-idiotypic serum against C3 H.SW anti-poly(LTyr, LGlu)-poly(DLAla)--poly(LLys)[(T,G)-A--L] antibodies was elicited in C57BL/6 mice. The effect of the anti-idiotypes on the proliferation of primed lymph node cells was investigated. The anti-idiotypic serum stimulated the proliferative response of the (T,G)-A--L-specific lymph node cells as well as of nylon wool-enriched T cells. In the presence of suboptimal doses of (T,G)-A--L, the addition of the anti-idiotypes enhanced the proliferation to the levels obtained with the optimal dose of (T,G)-A--L itself. These results suggest the existence of shared idiotypic determinants between antibodies and the (T,G)-A--L-specific proliferative T cells.
在C57BL/6小鼠中诱导产生了针对C3H.SW抗聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）-聚（L-赖氨酸）[（T，G）-A-L]抗体的鼠抗独特型血清。研究了抗独特型对致敏淋巴结细胞增殖的影响。抗独特型血清刺激了（T，G）-A-L特异性淋巴结细胞以及尼龙毛富集的T细胞的增殖反应。在次优剂量的（T，G）-A-L存在下，添加抗独特型可将增殖增强至用最佳剂量的（T，G）-A-L本身所达到的水平。这些结果表明抗体与（T，G）-A-L特异性增殖性T细胞之间存在共同的独特型决定簇。
