抗独特型抗体引发对聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）-聚（L-赖氨酸）的迟发型超敏反应
Elicitation of delayed-type hypersensitivity responses to poly(L-Tyr,LGlu)-poly(DLAla)--poly(LLys) by anti-idiotypic antibodies.
作者信息
Strassmann G, Lifshitz R, Mozes E
出版信息
J Exp Med. 1980 Nov 1;152(5):1448-52. doi: 10.1084/jem.152.5.1448.
Abstract
The in vivo effect of murine anti-idiotypic serum against C3H.SW anti-poly(LTyr,LGlu)-poly(DLAla)-(LLys) [(T,G)-A--L] antibodies on delayed type hypersensitivity responses to (T,G)-A--L was studied. Anti-idiotypic serum could challenge DTH responses in C3H.SW mice transferred with antigen-sensitized T cells. The elicitation activity was shown to be antigen and strain specific. With H-2-compatible (but allotype different) strain combinations of (T,G)-A--L-educated T cells and recipients, we were able to show that the biological effect of the anti-idiotypic serum is expressed on the first antigen-sensitized idiotype-positive radioresistant T cell, but not on the proliferating normal cells of recipient origin that participate in the efferent phase of delayed-type hypersensitivity responses to (T,G)-A--L.
摘要
研究了鼠抗独特型血清针对C3H.SW抗聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）-（L-赖氨酸）[（T，G）-A-L]抗体对（T，G）-A-L迟发型超敏反应的体内效应。抗独特型血清可激发用抗原致敏T细胞转移的C3H.SW小鼠的迟发型超敏反应。激发活性显示为抗原特异性和品系特异性。通过（T，G）-A-L致敏的T细胞与受体的H-2相容（但异型不同）品系组合，我们能够证明抗独特型血清的生物学效应表现在首个抗原致敏的独特型阳性辐射抗性T细胞上，而不是表现在参与对（T，G）-A-L迟发型超敏反应传出相的受体来源的增殖正常细胞上。
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Elicitation of delayed-type hypersensitivity responses to poly(L-Tyr,LGlu)-poly(DLAla)--poly(LLys) by anti-idiotypic antibodies.抗独特型抗体引发对聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）-聚（L-赖氨酸）的迟发型超敏反应
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5
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