Eidelberg E, Story J L, Walden J G, Meyer B L
Exp Brain Res. 1981;42(1):81-8. doi: 10.1007/BF00235732.
We trained cats to walk on a moving treadmill belt, then subjected them to partial transverse sections of the thoracic spinal cord. Afterwards, we observed their ability to walk on the treadmill, over a period of several weeks, using gait analysis techniques to describe the resultant deficits. The extent of the lesions was verified histologically, and the identity of the spared descending axons from the brain stem was demonstrated by retrograde labeling with horseradish peroxidase. We found that significant sparing or recovery of hindlimb locomotor function is closely linked to sparing of axons in at least one ventrolateral quadrant of the cord. The essential elements probably belong to vestibulospinal and reticulospinal systems.
我们训练猫在移动的跑步机皮带上行走，然后对它们进行胸段脊髓部分横切。之后，我们观察它们在跑步机上行走的能力，持续数周，使用步态分析技术来描述由此产生的缺陷。通过组织学方法验证损伤程度，并用辣根过氧化物酶逆行标记法证明从脑干发出的 spared 下行轴突的身份。我们发现，后肢运动功能的显著 spared 或恢复与脊髓至少一个腹外侧象限中轴突的 spared 密切相关。基本要素可能属于前庭脊髓和网状脊髓系统。
