Steeves J D, Jordan L M
Neurosci Lett. 1980 Dec;20(3):283-8. doi: 10.1016/0304-3940(80)90161-5.
The spinal cord pathways which are important for controlled treadmill locomotion evoked by stimulation of the mesencephalic locomotor region (MLR) were investigated in cats subjected to subtotal spinal cord lesions at the C1-C2 level. Locomotion could be evoked following bilateral lesions of the dorsal columns, the dorsolateral funiculi, and the ventromedial funiculi, and after combined lesions of the dorsolateral and ventromedial funiculi, but not after bilateral lesions of the ventrolateral quadrant. Unilateral lesions of the ventrolateral quadrant abolished locomotion in the limbs is ipsilateral to the lesion. It is suggested that MLR stimulation may give rise to locomotion by activation of pontine and medullary reticulospinal pathways projecting through the ventrolateral quadrant.
在C1 - C2水平遭受部分脊髓损伤的猫中，研究了对中脑运动区（MLR）刺激诱发的可控跑步机运动起重要作用的脊髓通路。双侧损伤背柱、背外侧索和腹内侧索后，以及背外侧索和腹内侧索联合损伤后，均可诱发运动，但腹外侧象限双侧损伤后则不能诱发运动。腹外侧象限的单侧损伤使损伤同侧肢体的运动消失。提示MLR刺激可能通过激活经腹外侧象限投射的脑桥和延髓网状脊髓通路而引发运动。
