Zisiadis S, Wüthrich B, Schnyder U W
Dermatologica. 1980;161(6):365-71.
15 patients with alopecia areata were treated with local application of DNCB in acetone over a period of 3-9 months. 9 of these had alopecia areata totalis, 3 had alopecia areata fere totalis, and 3 had common alopecia areata. The results are comparable with those of other authors. The response did not depend upon the duration of the disease but upon its extension. In all patients with alopecia areata and alopecia areata fere totalis, hair growth was induced, while only 2 of the 9 patients with alopecia areata totalis responded satisfactorily. One third of the latter were children in whom the treatment may be less effective than in adults. Contact allergy was induced in all but 1 case in which no hair growth occurred. Since the mutagenic effect of DNCB has been demonstrated in the Ames test, DNCB ought to be replaced by other haptens, but its possible cancerogenic effect must be tested in other in vivo models.
15名斑秃患者接受了丙酮中DNCB局部涂抹治疗，为期3 - 9个月。其中9人患有全秃，3人患有近全秃，3人患有普通斑秃。结果与其他作者的结果相当。疗效不取决于病程长短，而取决于病变范围。在所有斑秃和近全秃患者中均诱导出了毛发生长，而9名全秃患者中只有2人反应良好。后者中有三分之一是儿童，在儿童中治疗效果可能不如成人。除1例未发生毛发生长的病例外，其余均诱发了接触性过敏。由于在艾姆斯试验中已证实DNCB具有致突变作用，DNCB应该被其他半抗原替代，但其潜在的致癌作用必须在其他体内模型中进行检测。
