Happle R, Echternacht K
Z Hautkr. 1977 Nov 15;52(22):1129-34.
In 46 patients with alopecia areata, one side of the head was treated with weekly applications of DNCB, dissolved in acetone. The therapeutic aim was mild contact dermatitis. The other side of the head served as control region. A therapeutic effect was noted in 36 patients: 22 patients showed regrowth of hair exclusively on the treated side, and in 14 patients regrowth of hair was considerably faster and more dense on the treated side. In 8 patients no regrowth was observed, and in 2 patients regrowth occurred on both sides without any difference of intensity. The difference between both sides with regard to hair growth was seen in all of the 7 patients with moderate involvement and in 12 out of 13 patients with extensive involvement; but also in 17 out of 26 patients with alopecia areata totalis or fere totalis. The difference was noted, in the majority of cases, within 3 months. These results prove the efficacy of DNCB treatment of alopecia areata.
对46例斑秃患者，将头部一侧每周外用溶解于丙酮的二硝基氯苯（DNCB），治疗目标为产生轻度接触性皮炎。头部另一侧作为对照区域。36例患者有治疗效果：22例患者仅在治疗侧有毛发再生，14例患者治疗侧毛发再生明显更快且更浓密。8例患者未观察到毛发再生，2例患者两侧均有毛发再生且强度无差异。在7例中度受累患者以及13例广泛性受累患者中的12例中，两侧毛发再生存在差异；在26例全秃或接近全秃的斑秃患者中的17例中也存在差异。在大多数病例中，3个月内即可观察到差异。这些结果证明了DNCB治疗斑秃的有效性。
