van Ormondt H, Maat J, Dijkema R
Gene. 1980 Dec;12(1-2):63-76. doi: 10.1016/0378-1119(80)90016-5.
The early E1a regions (map position (0--4.5%) of highly oncogenic (subgroup A) adenovirus serotype 12 (Ad12), weakly oncogenic (subgroup B) adenovirus serotype 7 (Ad7) and non-oncogenic (subgroup C) adenovirus serotype 5 (Ad5) can convert cells in vitro into an immortal cell line. A comparison of the nucleotide sequences for the E1a regions of Ad12 (Sugisaki et al., 1980), Ad7 (Dijkema et al., 1980), and Ad5 (Van Ormondt et al., 1978) DNA is presented. The overall homology is about 50%, but certain segments of the E1a regions exhibit higher than average homology, for both coding and noncoding sequences. The latter may specify the initiation of DNA replication, DNA encapsidation and regulation of expression. The predicted polypeptides encoded by the E1a regions of the three serotypes exhibit a large degree of homology.
高致癌性（A亚组）腺病毒血清型12（Ad12）、弱致癌性（B亚组）腺病毒血清型7（Ad7）和非致癌性（C亚组）腺病毒血清型5（Ad5）早期的E1a区域（图谱位置为0至4.5%）可在体外将细胞转化为永生细胞系。本文对Ad12（杉崎等人，1980年）、Ad7（迪克马等人，1980年）和Ad5（范·奥蒙德特等人，1978年）DNA的E1a区域核苷酸序列进行了比较。总体同源性约为50%，但E1a区域的某些片段在编码序列和非编码序列方面均表现出高于平均水平的同源性。后者可能决定DNA复制的起始、DNA包装及表达调控。三种血清型E1a区域编码的预测多肽表现出高度同源性。
