Copper and zinc content of liver, heart, skeletal muscle, and brain, in acute thioacetamide intoxication of rats.

It has been demonstrated that acute thioacetamide intoxication causes a significant increase in copper and zinc in the dystrophic liver of rats. Heart, skeletal muscle, cerebrum and cerebellum showed neither significant deviations of copper and zinc content, nor noticeable histopathologic changes in comparison with controls. Thus, hepatotropia in thioacetamide intoxication receives minimal pathological confirmation.