Goepel J R
Histopathology. 1981 Jan;5(1):21-30. doi: 10.1111/j.1365-2559.1981.tb01763.x.
Six cases of localized benign papillary mesothelioma of peritoneum were retrieved from laboratory files over a 20-year period. One presented because of pain following torsion and the remaining five were incidental findings at operation. Light microscopy showed a delicate papillary stroma covered by a single layer of mesothelial cells. The mesothelial cells often showed punctate periodic acid-Schiff staining of cytoplasm. The brush border and stroma showed alcian blue positive staining which was abrogated by prior incubation with hyaluronidase. Electron microscopy revealed typical features of mesothelial cells with long microvilli, rough endoplasmic reticulum in relation to mitochondria, bundles of microfilaments, and tight junctions. Between cells there was a series of intercommunicating channels containing occasional lymphocytes and debris. These features are compared with nodular mesothelial hyperplasia, malignant mesothelioma and adenomatoid tumours of the genital tract. The necessity to distinguish benign papillary mesothelioma from metastatic carcinoma is stressed and relies on the recognition of their mesothelial origin.
在20年的时间里，从实验室档案中找出了6例局限性腹膜良性乳头状间皮瘤。其中1例因扭转后疼痛就诊，其余5例是手术中的偶然发现。光镜下可见纤细的乳头样间质被单层间皮细胞覆盖。间皮细胞的细胞质常显示点状过碘酸-希夫染色。刷状缘和间质显示阿尔辛蓝阳性染色，预先用透明质酸酶孵育可消除这种染色。电镜显示间皮细胞的典型特征，有长微绒毛、与线粒体相关的粗面内质网、微丝束和紧密连接。细胞之间有一系列相互连通的通道，偶尔含有淋巴细胞和碎屑。将这些特征与结节性间皮增生、恶性间皮瘤和生殖道腺瘤样肿瘤进行了比较。强调了将良性乳头状间皮瘤与转移性癌区分开来的必要性，这依赖于对它们间皮起源的认识。
