对致病性自由生活阿米巴的免疫：体液抗体的作用。
Immunity to pathogenic free-living amoebae: role of humoral antibody.
作者信息
Cursons R T, Brown T J, Keys E A, Moriarty K M, Till D
出版信息
Infect Immun. 1980 Aug;29(2):401-7. doi: 10.1128/iai.29.2.401-407.1980.
Abstract
Pathogenic free-living amoebae are common in nature, but few clinical infections by these amoebae have been reported. This has prompted studies of host susceptibility factors in humans. A survey of normal human sera from three New Zealand Health Districts was made; antibodies to pathogenic free-living amoebae were found in all sera, with titers ranging from 1:5 to 1:20 for Naegleria spp. and from 1:20 to 1:80 for Acanthamoeba spp. The antibodies belonged mainly to immunoglobulin G and immunoglobulin M classes. The presence of a specific neutralizing factor against Acanthamoeba spp. but not Naegleria spp. was demonstrated. Possible protective mechanisms are discussed.
摘要
致病性自由生活阿米巴在自然界中很常见，但这些阿米巴引起的临床感染报道较少。这促使人们对人类宿主易感性因素进行研究。对来自新西兰三个卫生区的正常人血清进行了调查；在所有血清中均发现了针对致病性自由生活阿米巴的抗体，内格里属阿米巴的抗体滴度范围为1:5至1:20，棘阿米巴属阿米巴的抗体滴度范围为1:20至1:80。这些抗体主要属于免疫球蛋白G和免疫球蛋白M类。已证明存在针对棘阿米巴属阿米巴而非内格里属阿米巴的特异性中和因子。文中讨论了可能的保护机制。
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