Sandor T, Utsonomyia R, Rumbaugh C, Sridhar B
Int J Biomed Comput. 1980 Nov;11(6):487-500. doi: 10.1016/0020-7101(80)90015-x.
Computer-aided operator-interactive densitometry was used to study the feasibility of quantitating the radiographic images of cerebral aneurysms. Contrast-filled tubings of varying diameter were used to investigate the linearity of the system and to assess the general accuracy and reproducibility of the densitometric method. To study the reproducibility of the technique on aneurysms, a vein pouch aneurysm model was developed in rabbits. Inter- and intra-operator errors were determined by four observers, who performed multiple measurements on various projections of aneurysm images taken both in vitro and in vivo. These errors ranged between 3 and 8% for the in vitro data, and 7 and 22% for the in vivo data. It was found that the current approach that utilizes the linear segment of the film-screen characteristic curve has to be extended to involve the non-linear segment at the 'toe' section of the characteristic curve for future clinical applications.
采用计算机辅助操作员交互式光密度测定法研究定量脑动脉瘤放射影像的可行性。使用不同直径的造影剂填充管来研究该系统的线性，并评估光密度测定法的总体准确性和可重复性。为了研究该技术在动脉瘤上的可重复性，在兔身上建立了静脉袋状动脉瘤模型。由四名观察者确定操作员间和操作员内误差，他们对在体外和体内拍摄的动脉瘤图像的各种投影进行了多次测量。体外数据的这些误差在3%至8%之间，体内数据的误差在7%至22%之间。结果发现，目前利用胶片-屏幕特性曲线线性部分的方法必须扩展，以纳入特性曲线“趾部”的非线性部分，用于未来的临床应用。
