抗甲状腺药物（卡比马唑）诱导大鼠甲状腺肥大期间的有丝分裂率
Mitotic rate of the rat's thyroid gland during hypertrophy induced by an antithyroid agent (carbimazole).
作者信息
Redmond O, Tuffery A R
出版信息
J Anat. 1978 Oct;127(Pt 2):353-62.
Female rats (200 g body weight) were either untreated or given carbimazole (0.1 g/100 ml) in their drinking water for up to 12 weeks. The mitotic rate of the thyroid follicular cells was estimated using vincristine sulphate. Measurement of whole-body oxygen consumption showed that the rats were clearly hypothyroid after 1 week of treatment. The mitotic rate rose rapidly from the control value of 3.65% metaphases/day to about 25%/day after 4 days and was maintained at this level for at least 5 weeks of treatment. The changes in mitotic rate were apparently synchronous with the histological changes. The results of earlier studies are reviewed and discussed in relation to recent concepts of cell populations.
雌性大鼠（体重200克）分为未处理组和在饮用水中给予卡比马唑（0.1克/100毫升）长达12周的处理组。使用硫酸长春新碱估计甲状腺滤泡细胞的有丝分裂率。全身耗氧量的测量表明，处理1周后大鼠明显甲状腺功能减退。有丝分裂率从对照值中期3.65%/天迅速上升至4天后约25%/天，并在至少5周的处理期间维持在该水平。有丝分裂率的变化显然与组织学变化同步。结合细胞群体的最新概念对早期研究结果进行了回顾和讨论。
Zotero 插件