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关节腔内注射皮质类固醇和水杨酸盐对关节软骨表面结构的影响。

Effects of intra-articularly administered corticosteroids and salicylates on the surface structure of articular cartilage.

作者信息

Lutfi A M, Kosel K

出版信息

J Anat. 1978 Oct;127(Pt 2):393-402.

PMID:721699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1235779/
Abstract

This study was designed to evaluate the effects of repeated intra-articular corticosteroid and salicylate injections on the surface structure of articular cartilage in the rabbit, using the scanning electron miscroscope. We have shown that the normal surface of the rabbit's articular cartilage presents shallow depressions and mound-like elevations and that corticosteroid-treated articular cartilage exhibits progressive lesions, including fissuring and fraying. The effects of salicylates require further investigation.

摘要

本研究旨在利用扫描电子显微镜评估反复关节内注射皮质类固醇和水杨酸盐对兔关节软骨表面结构的影响。我们已经表明，兔关节软骨的正常表面呈现出浅凹陷和丘状隆起，而经皮质类固醇处理的关节软骨表现出进行性病变，包括裂隙和磨损。水杨酸盐的作用需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/c09d17428afa/janat00354-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/83ecb7036813/janat00354-0171-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/da5fa0e26c1a/janat00354-0171-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/b12d86e99c47/janat00354-0172-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/d9ccf341d578/janat00354-0172-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/13b911ef0651/janat00354-0173-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/c1ee20138967/janat00354-0173-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/b567d2dcfb26/janat00354-0174-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/939c9e2792e8/janat00354-0174-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/c09d17428afa/janat00354-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/83ecb7036813/janat00354-0171-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/da5fa0e26c1a/janat00354-0171-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/b12d86e99c47/janat00354-0172-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/d9ccf341d578/janat00354-0172-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/13b911ef0651/janat00354-0173-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/c1ee20138967/janat00354-0173-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/b567d2dcfb26/janat00354-0174-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/939c9e2792e8/janat00354-0174-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ab/1235779/c09d17428afa/janat00354-0175-a.jpg

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本文引用的文献

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Electron microscopy of articular cartilage in the young adult rabbit.成年幼兔关节软骨的电子显微镜检查
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Steroid arthropathy of the hip.髋关节类固醇性关节病
曲安奈德缓释剂单次及重复关节腔内注射后的局部效应：来自三项犬类非临床毒性研究的结果
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The Effect of Intra-articular Corticosteroids on Articular Cartilage: A Systematic Review.关节内皮质类固醇对关节软骨的影响：系统评价。
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The chondrotoxicity of single-dose corticosteroids.单次剂量皮质类固醇的软骨毒性。
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The effect of local corticosteroid or ketorolac exposure on histologic and biomechanical properties of rabbit tendon and cartilage.局部使用皮质类固醇或酮咯酸对兔肌腱和软骨的组织学及生物力学特性的影响。
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Physiological levels of hydrocortisone maintain an optimal chondrocyte extracellular matrix metabolism.生理水平的氢化可的松维持软骨细胞外基质的最佳代谢。
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