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致癌物铬酸盐会在大鼠肝脏和肾脏中诱导DNA交联。

The carcinogen chromate induces DNA cross-links in rat liver and kidney.

作者信息

Tsapakos M J, Hampton T H, Jennette K W

出版信息

J Biol Chem. 1981 Apr 25;256(8):3623-6.

PMID:7217049
Abstract

DNA cross-links were found in nuclei isolated from the liver and kidney of rats treated with chromate. A dose-dependent relationship between chromate exposure and total DNA cross-links was determined using the alkaline elution technique. DNA cross-links in kidney were mainly DNA-protein in nature. Chromate also induced a small amount of interstrand DNA cross-links in kidney. Liver nuclei contained protein-associated DNA single strand breaks in addition to DNA-protein cross-links. The organotropic DNA damage induced by chromate is discussed in relation to the carcinogenicity and toxicity of chromium(VI) compounds.

摘要

在从用铬酸盐处理过的大鼠的肝脏和肾脏中分离出的细胞核中发现了DNA交联。使用碱性洗脱技术确定了铬酸盐暴露与总DNA交联之间的剂量依赖关系。肾脏中的DNA交联主要是DNA-蛋白质性质的。铬酸盐还在肾脏中诱导了少量的链间DNA交联。除了DNA-蛋白质交联外，肝细胞核还含有与蛋白质相关的DNA单链断裂。讨论了铬酸盐诱导的器官特异性DNA损伤与六价铬化合物的致癌性和毒性的关系。

相似文献

1
The carcinogen chromate induces DNA cross-links in rat liver and kidney.致癌物铬酸盐会在大鼠肝脏和肾脏中诱导DNA交联。
J Biol Chem. 1981 Apr 25;256(8):3623-6.
2
Chromium(VI)-induced DNA lesions and chromium distribution in rat kidney, liver, and lung.六价铬诱导的大鼠肾脏、肝脏和肺中的DNA损伤及铬分布。
Cancer Res. 1983 Dec;43(12 Pt 1):5662-7.
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Cancer Res. 1982 Sep;42(9):3544-9.
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Transcriptional inhibition by carcinogenic chromate: relationship to DNA damage.致癌性铬酸盐对转录的抑制作用：与DNA损伤的关系
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DNA-protein cross-linking by chromium salts.铬盐导致的DNA-蛋白质交联
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The carcinogen chromate causes DNA damage and inhibits drug-mediated induction of porphyrin accumulation and glucuronidation in chick embryo hepatocytes.致癌物铬酸盐会导致DNA损伤，并抑制药物介导的雏鸡胚胎肝细胞中卟啉积累和葡萄糖醛酸化的诱导。
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Differential DNA-protein crosslinking in lymphocytes and liver following chronic drinking water exposure of rats to potassium chromate.大鼠长期饮用含铬酸钾的水后淋巴细胞和肝脏中DNA-蛋白质交联的差异
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Characterization of the hepatic DNA damage caused by 1,2-dibromoethane using the alkaline elution technique.使用碱性洗脱技术对1,2 - 二溴乙烷引起的肝脏DNA损伤进行表征。
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引用本文的文献

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Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity.形成基于铬的链间 DNA 交联：致癌性的影响。
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In vitro assessment of the toxicity of metal compounds : IV. Disposition of metals in cells: Interactions with membranes, glutathione, metallothionein, and DNA.金属化合物的体外毒性评估：IV. 金属在细胞内的分布：与膜、谷胱甘肽、金属硫蛋白和 DNA 的相互作用。
Biol Trace Elem Res. 1984 Apr;6(2):139-58. doi: 10.1007/BF02916931.
3
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Biol Trace Elem Res. 1983 Feb;5(1):55-71. doi: 10.1007/BF02916927.
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Coordination chemistry and the carcinogenicity and mutagenicity of chromium(VI).配位化学与六价铬的致癌性和致突变性。
Environ Geochem Health. 1989 Dec;11(3-4):77-85. doi: 10.1007/BF01758655.
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Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.评估经口接触六价铬后诱发啮齿类动物小肠肿瘤的作用机制及其与人类的相关性。
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