Joyeux H, Joyeux A, Carretier M, Raoux P, Ould Said H, Saint-Aubert B, Blanc F, Rouanet C, Pujol H, Solassol C
J Chir (Paris). 1980 Mar;117(3):199-204.
After subtotal (90%) or total hepatectomy in the dog, coagulation disturbances appear early and exclude survival beyond 40 hours. These disturbances are the result of a fall in the synthesis of coagulation factors, but may also reflect a consumption syndrome. The ensuing clinical finding is an intravascular coagulation which can give way to fibrinolysis. A substitutive therapy aiming to replace the missing factors and avoid or prevent an eventual consumption thus appears necessary. The hemostatic disturbances after subtotal or total hepatectomy in the dog can be totally corrected by a substitutive therapy based on fresh frozen plasma. The first hepatic segment (caudate lobe) cannot insure by itself the coagulation functions during the first 4 post-op days. The hemostatic assistance is an other step towards the treatment of hepatic insufficiency. It must become an integral part of existing artificial liver support.
在犬行次全（90%）或全肝切除术后，凝血功能紊乱出现较早，导致动物存活时间不超过40小时。这些紊乱是凝血因子合成减少的结果，但也可能反映了一种消耗综合征。随之出现的临床症状是血管内凝血，进而可能发展为纤维蛋白溶解。因此，一种旨在补充缺失因子并避免或预防最终消耗的替代疗法显得很有必要。基于新鲜冷冻血浆的替代疗法可完全纠正犬次全或全肝切除术后的止血紊乱。在术后的头4天里，第一肝段（尾状叶）自身无法确保凝血功能。止血辅助是治疗肝功能不全的又一举措。它必须成为现有人工肝支持的一个组成部分。
