Lal H, Shearman G T, Ursillo R C
J Clin Pharmacol. 1981 Jan;21(1):16-9. doi: 10.1002/j.1552-4604.1981.tb01726.x.
Clonidine (0.01 to 0.16 mg/kg) and lofexidine (0.01 to 0.64 mg/kg) produced a dose-dependent inhibition of diarrhea induced by castor oil treatment in the rat. Both drugs were more potent and longer acting than diphenoxylate. Pre- and posttreatment with naloxone (5 mg/kg) failed to prevent or antagonize the antidiarrheal effect of clonidine and lofexidine. These data suggest that clonidine and lofexidine may provide potent antidiarrheal activity of a nonnarcotic nature.
可乐定（0.01至0.16毫克/千克）和洛非西定（0.01至0.64毫克/千克）对蓖麻油诱发的大鼠腹泻产生剂量依赖性抑制作用。两种药物比地芬诺酯更有效且作用时间更长。纳洛酮（5毫克/千克）预处理和后处理未能预防或拮抗可乐定和洛非西定的止泻作用。这些数据表明，可乐定和洛非西定可能具有强效的非麻醉性止泻活性。
