贯叶金丝桃甲醇叶提取物对实验性腹泻的止泻作用。
Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea.
机构信息
Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.
出版信息
Asian Pac J Trop Med. 2012 Feb;5(2):147-50. doi: 10.1016/S1995-7645(12)60014-5.
OBJECTIVE
To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.
METHODS
The methanol leaf extract of Pterocarpus erinaceus was evaluated using different doses (100, 200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea, charcoal meal transit time and castor oil-induced enteropooling in different groups of albino Wistar mice. The activity of the extract at different doses were compared to diphenoxylate (5 mg/kg) and atropine sulphate (3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.
RESULTS
The extract at the doses used caused a significant (P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea, decreased the distance travelled by the charcoal meal by up to 54.8% and also caused a dose dependent and significant (P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling.
CONCLUSIONS
Our results indicate that Pterocarpus erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.
目的
研究紫檀甲醇叶提取物在体内的抗腹泻活性。
方法
采用不同剂量（100、200 和 400 mg/kg 体重）口服，通过蓖麻油诱导的腹泻、炭粒传递时间和蓖麻油诱导的肠液积聚，在不同组别的白化 Wistar 小鼠中评估紫檀甲醇叶提取物的抗腹泻活性。将提取物在不同剂量下的活性与地芬诺酯（5 mg/kg）和硫酸阿托品（3 mg/kg）进行比较，地芬诺酯和硫酸阿托品分别用作标准参考药物，同时与给予蒸馏水的小鼠阴性对照组进行比较。
结果
使用的提取物剂量可显著（P<0.01）减少蓖麻油诱导的腹泻中小鼠的湿粪便排出量，使炭粒传递距离减少多达 54.8%，并在剂量依赖性和显著（P<0.001）水平上减少蓖麻油诱导的肠液积聚中的腔内液体积累。
结论
我们的结果表明，紫檀提取物具有显著的抗腹泻活性，其作用可能归因于抑制胃肠道运动和液体分泌。
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