Goldgeier M H, Cohen S R, Braverman I M, Stenn K S
J Am Acad Dermatol. 1981 Feb;4(2):176-80. doi: 10.1016/s0190-9622(81)70021-5.
A patient with plaque stage mycosis fungoides (MF) developed an atypical disseminated cutaneous herpes simplex virus (HSV) infection manifested by polycyclic cutaneous ulcers. Although Tzanck preparations and serial antibody titers to herpes virus were negative, the diagnosis was readily established by viral culture and histologic examination of the skin lesions. Following adenine arabinoside therapy, the viral cultures of the ulcers became negative and the spread of virus-induced ulcerations ceased. In an immunocompromised host with rapidly advancing, sharply punched-out polycyclic cutaneous ulcerations, herpes simplex infection should be considered even though the classical vesicular lesions are absent.
一名斑块期蕈样肉芽肿（MF）患者发生了非典型播散性皮肤单纯疱疹病毒（HSV）感染，表现为多环状皮肤溃疡。尽管Tzanck涂片检查及针对疱疹病毒的系列抗体滴度均为阴性，但通过病毒培养和皮肤病变的组织学检查很容易确诊。接受阿糖腺苷治疗后，溃疡的病毒培养转为阴性，病毒诱导的溃疡扩散停止。在免疫功能低下的宿主中，若出现迅速进展、边界清晰的多环状皮肤溃疡，即使没有典型的水疱性损害，也应考虑单纯疱疹感染。
