Evidence for increased susceptibility of Brugia pahangi-infected jirds (Meriones unguiculatus) to subsequent homologous infections.

The effect of existing Brugia pahangi infections on the establishment of a subsequent population was studied using jirds which had pre-challenge infections of 4 and 8 months duration. Necropsies were performed 28 days post-challenge inoculation in order to separate challenge and initial worm populations. The results indicate that existing infections of 4 or 8 months duration increase the susceptibility to subsequent homologous infections. The location of challenge population worms in tissue sites examined did not differ significantly between previously infected and uninfected groups. Previous infections did not affect the early growth of challenge population worms as indicated by their length.