Johnson E M
J Environ Pathol Toxicol. 1980 Nov;4(5-6):153-6.
The multiplicity of potential teratogenic mechanisms requires that a practical screening system for developmental hazards simultaneously assess effects on as wide a variety of developmental phenomena as possible. The system also must provide the relevant dose level based on adult toxicity. A fresh water coelenterate fashioned into an artificial "embryo" may provide the former, while exposure of adult polyps may provide the latter. The system appears to separate the two dose levels as adequately as standard laboratory rodents but as significantly lower cost in time and effort.
潜在致畸机制的多样性要求一个实用的发育危害筛查系统同时评估对尽可能广泛的各种发育现象的影响。该系统还必须根据成人毒性提供相关剂量水平。将淡水腔肠动物制成人工“胚胎”可能满足前者的要求，而成体息肉的暴露则可能满足后者的要求。该系统似乎能像标准实验室啮齿动物一样充分区分这两个剂量水平，但在时间和精力上的成本要低得多。
