Tardiff R G, Robinson M, Ulmer N S
J Environ Pathol Toxicol. 1980 Nov;4(5-6):267-75.
Groups of young adult rats of both sexes were exposed to 0, 10, 50, or 250 mg/liter (ppm) of barium as barium chloride in drinking water for 4, 8, or 13 weeks. No adverse effects related to barium ingestion were observed in food consumption, clinical signs, body weight, hematologic parameters (i.e., hemoglobin, hematocrit, red cell count, leukocyte count, prothrombin time, and fibrinogen), serum enzyme activities (i.e., SGOT, SGPT, and blood urea nitrogen), serum ions (i.e., Na, K, and Ca), gross pathology, and histopathology. Water consumption was slightly depressed in the highest dose group. A slight decrease in the relative weight of adrenals of treated vs. control animals was observed. Increasing dose, but not duration of exposure, produced related increases in barium concentrations in liver, skeletal muscle, heart, and bone, with the highest concentrations observed in bone.
将不同性别的成年幼鼠分组，使其饮用含0、10、50或250毫克/升（ppm）氯化钡形式钡的水，持续4、8或13周。在食物消耗、临床症状、体重、血液学参数（即血红蛋白、血细胞比容、红细胞计数、白细胞计数、凝血酶原时间和纤维蛋白原）、血清酶活性（即谷草转氨酶、谷丙转氨酶和血尿素氮）、血清离子（即钠、钾和钙）、大体病理学和组织病理学方面，未观察到与钡摄入相关的不良反应。最高剂量组的水消耗量略有下降。观察到处理组动物与对照组动物相比，肾上腺相对重量略有下降。剂量增加而非暴露持续时间增加，会使肝脏、骨骼肌、心脏和骨骼中的钡浓度相应增加，骨骼中的浓度最高。
