Rydevik B, Nordborg C
J Neurol Neurosurg Psychiatry. 1980 Dec;43(12):1070-82. doi: 10.1136/jnnp.43.12.1070.
Rabbit tibial nerves were subjected to direct, acute graded compression by means of an inflatable compression chamber. The acute and long term effects of 50, 200 and 400 mmHg applied for two hours on nerve function and nerve fibre structure were investigated. A pressure of 50 mmHg applied for two hours induced only minimal or no acute deterioration of maximal conduction velocity and nerve fibre structure. Conduction velocity was gradually reduced during compression at 200-400 mmHg pressure for two hours and in those cases the recovery of nerve conduction after pressure release was incomplete. Ultrastructural analysis revealed pronounced, early nerve fibre damage in these nerves. Three weeks after compression, nerves compressed at 50 mmHg for two hours had normal afferent and motor conduction velocity, although there were morphological signs of slight nerve fibre damage. Nerves compressed at 200 mmHg for two hours exhibited reduction of conduction velocity only at the level of compression, in contrast to the nerves compressed at 400 mmHg for two hours in which conduction velocity was reduced both at the level of compression and distal to the compressed segment. Morphologically, the nerves compressed at 200-400 mmHg for two hours showed varying degrees of demyelination and axonal degeneration three weeks after compression.
通过一个可充气的压迫腔对兔胫神经施加直接、急性分级压迫。研究了分别施加50、200和400 mmHg压力两小时对神经功能和神经纤维结构的急性和长期影响。施加50 mmHg压力两小时仅引起最大传导速度和神经纤维结构的轻微急性恶化或无恶化。在200 - 400 mmHg压力下压迫两小时期间，传导速度逐渐降低，并且在这些情况下，压力释放后神经传导的恢复不完全。超微结构分析显示这些神经中存在明显的早期神经纤维损伤。压迫三周后，施加50 mmHg压力两小时的神经具有正常的传入和运动传导速度，尽管存在轻微神经纤维损伤的形态学迹象。施加200 mmHg压力两小时的神经仅在压迫部位出现传导速度降低，而施加400 mmHg压力两小时的神经在压迫部位及其远端均出现传导速度降低。形态学上，施加200 - 400 mmHg压力两小时的神经在压迫三周后显示出不同程度的脱髓鞘和轴突变性。
