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一名患有“双重分离综合征”患者语言能力的神经语言学分析:一例存在混合性经皮质失语症的角回下失读症病例

Neurolinguistic analysis of the language abilities of a patient with a "double disconnection syndrome": a case of subangular alexia in the presence of mixed transcortical aphasia.

作者信息

Pirozzolo F J, Kerr K L, Obrzut J E, Morley G K, Haxby J V, Lundgren S

出版信息

J Neurol Neurosurg Psychiatry. 1981 Feb;44(2):152-5. doi: 10.1136/jnnp.44.2.152.

DOI:10.1136/jnnp.44.2.152
PMID:7217972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC490848/
Abstract

In contrast to the classic form of alexia without agraphia, subangular alexia results from a single lesion located deep in the white matter of the left parietal lobe. In the present report, a patient with subangular alexia and features of mixed transcortical aphasia is described. Neurolinguistic findings include: alexia without agraphia, paucity of spontaneous speech, moderate auditory comprehension difficulty, excellent repetition, echopraxia, colour agnosia, and naming disorder. Neurolinguistic tests revealed intact phonological organisation and grammatical filter." Our studies revealed a "double disconnection syndrome," the co-existence of two relatively rare neurobehavioural disorders. Furthermore, the studies reported here clearly show dissociations of language functions in both the visual and auditory modality, which demonstrates that the stages of language processing are separable.

摘要

与经典型失读不伴失写症不同,角回下失读症是由位于左侧顶叶白质深部的单个病灶引起的。在本报告中,描述了一名患有角回下失读症和混合性经皮质失语症特征的患者。神经语言学发现包括:失读不伴失写、自发言语匮乏、中度听觉理解困难、复述良好、模仿动作、颜色失认和命名障碍。神经语言学测试显示语音组织和语法筛选功能完好。我们的研究揭示了一种“双重分离综合征”,即两种相对罕见的神经行为障碍并存。此外,这里报告的研究清楚地表明了语言功能在视觉和听觉模式上的分离,这证明了语言处理阶段是可分离的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab69/490848/fa09c9e4cf55/jnnpsyc00058-0065-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab69/490848/fa09c9e4cf55/jnnpsyc00058-0065-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab69/490848/fa09c9e4cf55/jnnpsyc00058-0065-a.jpg

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引用本文的文献

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Alexia without agraphia or hemianopia in parietal infarction.顶叶梗死所致无失写症或偏盲的失读症
J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):841-2. doi: 10.1136/jnnp.54.9.841.

本文引用的文献

1
Disconnexion syndromes in animals and man. I.动物与人的分离综合征。I.
Brain. 1965 Jun;88(2):237-94. doi: 10.1093/brain/88.2.237.
2
Alexia without agraphia or hemianopsia. Anatomical analysis of an autopsied case.无失写症或偏盲的失读症。一例尸检病例的解剖学分析。
Brain. 1973 Jun;96(2):307-16. doi: 10.1093/brain/96.2.307.
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Subangular alexia without agraphia or hemianopsia.
Brain Lang. 1976 Apr;3(2):229-45. doi: 10.1016/0093-934x(76)90019-5.
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Repetition in the transcortical aphasias.经皮质性失语中的复述现象。
Brain Lang. 1978 Sep;6(2):226-38. doi: 10.1016/0093-934x(78)90060-3.